FISH is a sensitive method for detecting chromosomal abnormalities, particularly effective for identifying common aneuploidies in uncultured amniocytes within 24-48 hours.
FISH is a sensitive method for detecting chromosomal abnormalities, particularly effective for identifying common aneuploidies (abnormal numbers of chromosomes) in uncultured amniocytes within 24-48 hours. It complements routine chromosome analysis but should be used with more than just diagnosing common aneuploidy conditions.
FISH rapidly tests the number of selected chromosomes in the placenta, amniotic fluid, or fetal blood samples, providing diagnostic and prognostic information. Results are confirmed with karyotyping or microarray analysis.
When it is done : 16 weeks of pregnancy onwards
Tested Chromosomes:
The standard set includes chromosomes 13, 18, 21, X, and Y. Additional probes can be requested for specific conditions (e.g., 22q11.2 deletion syndrome).
Specimen Collection:
Samples are obtained from:
Report Time:
Results are typically available within 3-4 working days.
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The FISH (Fluorescence In Situ Hybridization) test is a rapid genetic test used during pregnancy to detect common chromosomal abnormalities in the fetus. It identifies conditions like Down syndrome (Trisomy 21), Trisomy 18, Trisomy 13, and sex chromosome abnormalities with high accuracy.
The FISH test is recommended when there is a higher risk of chromosomal abnormalities due to factors such as advanced maternal age, abnormal ultrasound findings, positive screening results, or a family history of genetic disorders. It provides quick preliminary results to guide further decisions.
The FISH test is usually performed from 16 weeks of pregnancy onwards, most commonly using amniotic fluid obtained through amniocentesis. It can also be done earlier using chorionic villus sampling (CVS).
The standard FISH test checks chromosomes 13, 18, 21, X, and Y, which are responsible for the most common chromosomal disorders. Additional probes can be requested for specific genetic conditions like 22q11.2 deletion syndrome.
FISH test results are typically available within 3–4 working days, making it much faster than conventional karyotyping, which can take 2–3 weeks.
The FISH test is highly accurate for detecting the specific chromosomes it targets. However, it is considered a rapid screening or preliminary diagnostic test, and results are usually confirmed with karyotyping or microarray analysis for complete chromosomal evaluation.
The FISH test can be performed on samples obtained from:
Amniotic fluid (Amniocentesis)
Placental tissue (Chorionic Villus Sampling – CVS)
Fetal blood, if required
Yes, the FISH test itself is safe. It is performed on samples collected through standard prenatal procedures like amniocentesis or CVS, which are done under expert medical supervision with strict safety protocols.
The FISH test can detect common chromosomal conditions such as:
Down syndrome (Trisomy 21)
Edwards syndrome (Trisomy 18)
Patau syndrome (Trisomy 13)
Turner syndrome
Klinefelter syndrome
Selected microdeletion syndromes (on request)
You can get the FISH test done at add-on Scans & Labs, where experienced specialists use advanced technology to ensure accurate, confidential, and timely results with comprehensive care.
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We add-on scans and labs strive to be the first choice in healthcare by providing high quality services to improve diagnostic services in health care.
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call +91-9900811118 or visit our website